Progressive Ankylosis Gene <i>(ank)</i> Regulates Osteoblast Differentiation
نویسندگان
چکیده
منابع مشابه
Progressive ankylosis gene (ank) regulates osteoblast differentiation.
The progressive ankylosis gene (ank) is a transmembrane protein that transports intracellular pyrophosphate to the extracellular milieu. Human mutations of ank lead to craniometaphyseal dysplasia, a disease which is characterized by the overgrowth of craniofacial bones and osteopenia in long bones, suggesting that ANK plays a regulatory role in osteoblast differentiation. To determine the role ...
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INTRODUCTION Extracellular ATP (eATP) is released by articular chondrocytes under physiological and pathological conditions. High eATP levels cause pathologic calcification, damage cartilage, and mediate pain. We recently showed that stable over-expression of the progressive ankylosis gene product, ANK, increased chondrocyte eATP levels, but the mechanisms of this effect remained unexplored. Th...
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PURPOSE OF REVIEW Among the myriad of players in the calcification of cartilage, ANK is a relatively new entrant. It is a multipass transmembrane protein that regulates the transport of inorganic pyrophosphate between the cell and the extracellular space. Mutations in ANK result in two distinct calcification disorders: craniometaphyseal dysplasia and familial calcium pyrophosphate dihydrate dep...
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ژورنال
عنوان ژورنال: Cells Tissues Organs
سال: 2008
ISSN: 1422-6405,1422-6421
DOI: 10.1159/000151725